The pH can affect the activity of an enzyme-controlled reaction by (Select all that apply)

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affecting hydrogen bonding.affecting hydrogen bonding.
changing the shape of the enzymes active site.changing the shape of the enzymes active site.
altering the interaction between the substrate and the enzyme active site.altering the interaction between the substrate and the enzyme active site.
changing the ionic state of either the enzyme or the substrate.changing the ionic state of either the enzyme or the substrate.
altering the allosteric site.altering the allosteric site.

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