Use the passage to answer the question.

A scientist hypothesizes that dysregulated insulin signaling is responsible for the development of excess body fat in metabolic syndrome patients. Based on the data, which of these, if true, would BEST support this hypothesis?

Phosphorylated insulin receptor decreases the use of free energy in fibroblasts

Phosphorylated insulin receptor increases the use of free energy in fibroblasts.

Phosphorylated insulin receptor decreases the production of insulin in fibroblasts.

(1 point)

Metabolic Syndrome

0

100

Insulin (nM) Insulin Receptor

Metabolic syndrome is a clustering of various conditions including high blood pressure, high blood sugar, excess body fat, high serum triglycerides, and low high-density lipoproteins. Scientists studying metabolic syndrome cultured fibroblast cells from a metabolic syndrome patient and a healthy volunteer and challenged the cells to 100 nM insulin. Ten minutes after the stimulus was applied, they used a protein Immunoblot to measure the amount of phosphorylated insulin receptor in the cultures.

Healthy

100

0

Phosphorylated

Insulin Receptor

A)

Phosphorylated insulin receptor increases the production of insulin in fibroblasts.

B) Phosphorylated insulin receptor decreases the use of free energy in fibroblasts.