please Kindly suggest research statement of problems for the research topic, “Neuroantioxidative potential of Cucurbita pepo seed oil on methotrexate toxicity in female Wistar rats”.
1. The impact of methotrexate-induced oxidative stress on neurodegeneration in female Wistar rats and the potential neuroprotective effects of Cucurbita pepo seed oil.
2. Investigating the role of neuroantioxidants in mitigating methotrexate-induced cognitive impairment and neuroinflammation in a female rat model.
3. Evaluating the neuroprotective effects of Cucurbita pepo seed oil on methotrexate-induced neurotoxicity in female Wistar rats through analysis of oxidative stress markers and behavioral assessments.
4. Assessing the potential of Cucurbita pepo seed oil as an adjunct therapy for reducing neurotoxicity associated with methotrexate treatment in female Wistar rats.
5. Examining the mechanisms underlying the neuroantioxidative potential of Cucurbita pepo seed oil in ameliorating methotrexate-induced neurotoxicity in female Wistar rats, focusing on its effects on oxidative stress pathways and neuronal survival.