Using the negative connotation of a word instead of the positive can drastically change the tone and meaning of a sentence. For example, instead of saying "She was brave enough to confront the situation," if you were to say "She was foolish enough to confront the situation," it would imply that her actions were reckless or unwise rather than brave. This can give the reader a completely different interpretation of the situation and the character's motives. The negative connotation can also evoke different emotions and judgments from the reader, leading to a shift in the overall message conveyed by the sentence.
