Which mutation scenario will always lead to a natural selection would it be a mutation causes a specific advantage within the population, or a mutation causes an inactivated gene to be reactivated or a mutation causes a specific variation within the population, or a mutation causes a gene to become inactivated

The scenario that will always lead to natural selection is when a mutation causes a specific advantage within the population. Natural selection acts on variations in a population, where individuals with advantageous traits have a higher chance of survival and reproduction. Consequently, over time, these advantageous traits become more common in the population.

In the case where a mutation causes an inactivated gene to be reactivated, it may or may not lead to natural selection. The reactivated gene may provide an advantage, but it could also have no significant impact or even a disadvantageous effect. Whether or not it leads to natural selection depends on the specific advantage or disadvantage conferred by the reactivated gene.

Similarly, when a mutation causes a specific variation within the population, it may or may not lead to natural selection. The variation could be neutral or detrimental, leading to no or negative selection. On the other hand, if the specific variation provides an advantage, natural selection can act upon it.

When a mutation causes a gene to become inactivated, it can either lead to natural selection or not, depending on the function of the gene and its importance for survival or reproductive success. If the gene is not essential for survival or reproduction, the inactivation may have little impact on natural selection. However, if the gene is vital for an organism's fitness, individuals with the inactivated gene may have reduced survival or reproductive success, leading to negative selection.