Which of the following BEST describes how the Spanish and Hernando DeSoto impacted the Native Americans living in the southeastern region of North America?

☐ A. Native Americans benefitted from learning about new technologies from the Europeans.

B. They formed a strong alliance and became trading partners.

C. The Native Americans were introduced to new foods.

OD. Thousands of Native Americans died as a result of diseases spread by contact with Europeans.

OD. Thousands of Native Americans died as a result of diseases spread by contact with Europeans.