7 13

[__] 26
[__] 65
[__] 78
49 91

To determine the missing numbers in the sequence, we need to identify the pattern. Looking at the given numbers, it appears that each number in the first column is multiplied by 3 to get the number in the second column.

Using this pattern, we can find the missing numbers:

- 7 * 3 = 21
- 13 * 3 = 39

Therefore, the missing numbers are 21 and 39.