DDX for unilateral leg swelling

1. Deep vein thrombosis (DVT): This is the most common cause of unilateral leg swelling. It occurs when a blood clot forms in one of the deep veins of the leg, leading to swelling, pain, and warmth.

2. Cellulitis: This is a bacterial infection of the skin and underlying tissues, often caused by a break or injury to the skin. It can cause redness, warmth, and swelling in the affected leg.

3. Lymphedema: This is a condition where there is an accumulation of lymph fluid in the tissues, usually due to damage or obstruction of the lymphatic system. It can cause swelling, heaviness, and tightness in the leg.

4. Venous insufficiency: This occurs when the veins in the leg have difficulty returning blood back to the heart, leading to pooling of blood and swelling in the leg.

5. Baker's cyst: This is a fluid-filled swelling that forms behind the knee, usually due to an underlying knee problem such as osteoarthritis or a meniscal tear. It can cause swelling and discomfort in the leg.

6. Peripheral artery disease (PAD): This is a condition where there is narrowing or blockage of the arteries in the legs, leading to reduced blood flow. It can cause leg swelling, pain, and cramping during exercise.

7. Inflammatory conditions: Conditions such as rheumatoid arthritis or lupus can cause inflammation in the joints, leading to swelling in the affected leg.

8. Trauma or injury: A fracture, sprain, or other injury to the leg can cause localized swelling.

9. Tumors: Rarely, a tumor within the leg or pelvic area can cause unilateral leg swelling. This is more common in cases of cancer.

It is important to consult a healthcare professional for proper evaluation and diagnosis of the cause of unilateral leg swelling.