What is most responsible for preventing the Church from stopping the Protestant Reformation?

the spread of the bubonic plague
the sale of indulgences
the invention of the printing press
the concept of papal supremacy

The sale of indulgences and the concept of papal supremacy were significant factors that contributed to the Protestant Reformation, as they led to widespread dissatisfaction among the people with the Catholic Church and its practices. However, the most responsible factor that prevented the Church from stopping the Protestant Reformation was the invention of the printing press.

The printing press, invented by Johannes Gutenberg in the mid-15th century, played a crucial role in the spread of Protestant ideas and criticisms of the Catholic Church. Luther's Ninety-Five Theses, which ignited the Reformation, was printed and distributed widely, reaching a large audience much faster than would have been possible through handwritten copies. The printing press allowed the rapid dissemination of Protestant literature, including vernacular translations of the Bible, which enabled individuals to read and interpret the Scriptures for themselves, challenging traditional Catholic teachings.

The ability to mass-produce and distribute these ideas prevented the Church from effectively suppressing or containing the Reformation. It enabled reformers like Martin Luther, John Calvin, and others to gain a significant following, as their writings and ideas could reach far beyond their immediate surroundings. Consequently, the printing press played a pivotal role in spreading Protestantism and challenging the authority of the Catholic Church, ultimately preventing its efforts in halting the Reformation.