Which effect did Spanish and Portuguese colonization have on South American Indians

A Warfare, disease, and harsh treatment, including being forced to work in silver mines or sugar plantations, caused the deaths of many native people
B South American Indians were assimilated into the European ruling class
C Spanish and Portuguese colonization had less effect on South American Indians than it did on those native people living in Central America and the Caribbean.
D Many South American Indians emigrated to other parts of the Spanish or Portuguese empires.

A Warfare, disease, and harsh treatment, including being forced to work in silver mines or sugar plantations, caused the deaths of many native people.