What is frieds rule of dose and from where can we get 150 in these formula
Fried's rule is a pharmacokinetic formula used to estimate a pediatric dose based on a typical adult dose. The formula is as follows:
Pediatric Dose = (Age in years / (Age in years + 12)) x Adult Dose
This rule assumes that the metabolism of drugs in children is faster than in adults and therefore requires a lower dose.
To calculate a pediatric dose of 150 using Fried's rule, you would need to know the age of the child. Let's say the child's age is 8 years:
Pediatric Dose = (8 / (8 + 12)) x Adult Dose
Pediatric Dose = (8 / 20) x Adult Dose
Pediatric Dose = 0.4 x Adult Dose
To obtain a pediatric dose of 150 using this formula, you would need to know the corresponding adult dose. Divide 150 by 0.4 to get the adult dose:
Adult Dose = 150 / 0.4
Adult Dose = 375
So, if the adult dose is 375, then using Fried's rule with an 8-year-old child, the pediatric dose would be 150.