Which of the following drew a line across the US stating that any new state north of the line would be a free state and south of the line would be a slave state?

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Missouri Compromise
Monroe Doctrine
Prime Meridian
Mason Dixon

The correct answer is Mason Dixon. The Mason Dixon line, drawn in 1768-1769, was a boundary line between the northern and southern states in the United States. It was established to settle a border dispute between the states of Pennsylvania and Maryland, but later became a symbolic division between free and slave states.

The option that drew a line across the US stating that any new state north of the line would be a free state and south of the line would be a slave state is the "Mason Dixon" line.