If not repaired, uracil base-pairs with the purine named __(adenine??)___ resulting in a mutation during subsequent DNA replication.
Describe base pairing between uracil and the purine, i.e hydrogen bonding between hydrogen on N7 and oxygen on C2
here u go, hope it helps,
Uracil (/ˈjʊərəsɪl/; U) is one of the four nucleobases in the nucleic acid RNA that are represented by the letters A, G, C and U. The others are adenine (A), cytosine (C), and guanine (G). In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the uracil nucleobase is replaced by thymine. Uracil is a demethylated form of thymine.
Uracil is a common and naturally occurring pyrimidine derivative.[2] The name "uracil" was coined in 1885 by the German chemist Robert Behrend, who was attempting to synthesize derivatives of uric acid.[3] Originally discovered in 1900 by Alberto Ascoli, it was isolated by hydrolysis of yeast nuclein;[4] it was also found in bovine thymus and spleen, herring sperm, and wheat germ.[5] It is a planar, unsaturated compound that has the ability to absorb light.[6]
i needed something a little more specific but thanks
Base pairing is a fundamental process in DNA replication and repair, where complementary nucleotides come together and form hydrogen bonds to maintain the overall structure of the DNA molecule. In DNA, there are four types of nucleotides, each containing a nitrogenous base: adenine (A), cytosine (C), guanine (G), and thymine (T). However, in RNA, thymine is replaced by uracil (U).
When DNA replication occurs, the double-stranded DNA molecule unwinds, and each separated strand serves as the template for the synthesis of a new complementary strand. During this process, if the DNA is damaged and uracil is present instead of thymine, it can lead to potentially harmful mutations.
In the case of uracil, it can base-pair with the purine adenine. Adenine possesses a hydrogen atom on its nitrogen atom at position 7 (N7), while uracil contains an oxygen atom on its carbon atom at position 2 (C2). These two atoms can come into proximity and form a hydrogen bond, stabilizing the interaction between uracil and adenine. Specifically, the hydrogen on N7 of adenine forms a hydrogen bond with the oxygen on C2 of uracil.
It is worth noting that this base pairing between uracil and adenine should not occur in normal DNA. Instead, thymine (containing a methyl group in place of the oxygen atom) pairs specifically with adenine via two hydrogen bonds, providing more stability to the DNA structure. If uracil remains unrepaired and base pairs with adenine during subsequent replication, the DNA sequence will be altered, potentially leading to mutations and affecting the proper functioning of genes.