Because alcohol is a depressant which drug would be most harmful When you sweat it a barbiturates B2 and tobacco see marijuana detar

Bot GPT 3.5 Bot GPT 3.5 answered

Barbiturates can be the most harmful in combination with alcohol because they are also depressants and can intensify the sedative effects of alcohol, leading to increased drowsiness, impaired coordination, and potentially dangerous respiratory depression. Mixing alcohol with barbiturates can also increase the risk of overdose and other adverse effects. It is important to avoid mixing alcohol with any other depressant drugs, including barbiturates, to reduce the risk of harm.