When a person sneezes, the respiratory system detects irritants and signals the brain to initiate the sneeze reflex. Muscles in the chest, diaphragm, face, and throat work together to forcefully expel air and clear the irritant. The nervous system coordinates the sneeze reflex, while the immune system helps protect the body by releasing inflammatory mediators. These systems interact to rid the body of irritants and maintain respiratory health.

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When someone sneezes, their body's systems work together to protect them by getting rid of irritants and keeping their respiratory system healthy.