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To find the rate of change of y with respect to x, we can use the slope formula:
\[m = \frac{y_2 - y_1}{x_2 - x_1}\]
Using the coordinates (-3, 6) and (7, -4), we have:
\[m = \frac{(-4) - 6}{7 - (-3)} = \frac{-4 - 6}{7 + 3} = \frac{-10}{10} = -1\]
Therefore, the rate of change of y with respect to x for this line is -1.