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The introduction of diseases by the Europeans weakened the Aztec forces, leading them to join forces with the Totonac and Tlaxcalans against the Spaniards. The spread of disease also slowed the progression of battles between the two groups. Indigenous Americans had not been previously exposed to these diseases, and their immune systems were not able to tolerate them, which ultimately benefited the Spanish forces. However, it is important to note that while disease did weaken forces on both sides, the number of deaths from illness was relatively low.