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We can apply the property of integer exponents that states, when dividing two exponential expressions with the same base, we subtract the exponents. So, we have:
2^2 / 2^-4 = 2^(2-(-4)) = 2^6.
To further simplify, we can rewrite 2^6 with only positive exponents as:
2^6 = 2^(2*3) = (2^2)^3 = 4^3.
Finally, we solve the expression:
4^3 = 4 * 4 * 4 = 64.
Therefore, the solution is 64 as a whole number.