To simplify the given expression, let's break it down step by step:
Step 1: Calculate the power inside parentheses: (4 + 6)^2 = 10^2 = 100.
Step 2: Simplify 2^4 = 2 * 2 * 2 * 2 = 16.
Step 3: Calculate 4^0 = 1 (any number raised to the power of 0 is equal to 1).
Step 4: Combine the results: 16 * 100 / 1 = 1600 / 1 = 160.
Therefore, the simplified expression is 160.
So, the correct answer is 160.