According to the power rule of exponents, when we have a power raised to another power, we multiply the exponents.
So in this case, we can simplify (4^2)^2 as 4^(2*2).
This becomes 4^4, which can be further simplified as 4 * 4 * 4 * 4.
Therefore, (4^2)^2 simplifies to 256 as a whole number.