To simplify this expression, we can use the exponent rule that states:
a^m × a^n = a^(m + n)
So, applying this rule to 5^13 × 5^-10:
5^13 × 5^-10 = 5^(13 + (-10))
Since 13 + (-10) = 3, we have:
5^13 × 5^-10 = 5^3
Therefore, the simplified expression is 5^3.