To generate an equivalent expression with positive exponents, we can use the property of exponentiation that states:
\[a^{-n} = \frac{1}{a^n}\]
Applying this property to the given expression, we have:
\[4^0 \cdot 5^{-2} \cdot (-2)^{-3} = \frac{1}{4^0} \cdot \frac{1}{5^2} \cdot \frac{1}{(-2)^3}\]
Since any non-zero number to the power of 0 is equal to 1, we have:
\[\frac{1}{4^0} = \frac{1}{1} = 1\]
Now, we can use the property of exponentiation that states:
\[\frac{1}{a^{-n}} = a^n\]
to simplify the expression further:
\[\frac{1}{5^2} = 5^{-2}\]
and
\[\frac{1}{(-2)^3} = (-2)^{-3}\]
Therefore, the equivalent expression with positive exponents is:
\[1 \cdot 5^{-2} \cdot (-2)^{-3}\]
To solve the expression, we can evaluate the exponents:
\[1 \cdot 5^{-2} \cdot (-2)^{-3} = \frac{1}{5^2} \cdot \frac{1}{(-2)^3} = \frac{1}{25} \cdot \frac{1}{-8}\]
Simplifying the fraction, we have:
\[\frac{1}{25} \cdot \frac{1}{-8} = \frac{1}{-200}\]
Therefore, the final answer, written as a simplified fraction with no remaining exponents, is $\boxed{-\frac{1}{200}}$.