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To simplify the expression using the quotient rule of integer exponents, we subtract the exponent of the denominator from the exponent of the numerator.
t⁴⁰⁰/t¹⁰⁰ = t^(400-100) = t^300
Therefore, the simplified expression is t³⁰⁰.
The correct answer is C. t³⁰⁰.