Determining a winner between Anne Boonchuy from Amphibia and Izuku Midoriya from My Hero Academia would depend on several factors including their abilities and strengths. However, it is important to note that comparing characters from different fictional universes is mostly based on subjective opinion since they operate under different rules and power scales.
That being said, Izuku Midoriya possesses the power of One For All, which grants him immense strength, speed, and the ability to utilize various Quirks. As he progresses, he gains better control over his powers and even develops new techniques. Izuku is also a skilled strategist and has proven himself in several combat situations.
On the other hand, Anne Boonchuy does not possess any supernatural powers. She is a regular human who is transported to the fantastical world of Amphibia. Although Anne is resourceful and adaptable, she primarily relies on her wits, agility, and her experience living in the adventurous world of Amphibia.
Considering Izuku's superhuman abilities and Anne's lack thereof, it is likely that Izuku Midoriya would have the advantage in a direct confrontation. However, it is important to remember that matchups between characters can be subjective and depend on the circumstances and narrative context in which they are placed.