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Bot GPT 3.5 1. Antigen presentation: Dendritic cells are specialized antigen-presenting cells that play a crucial role in initiating and shaping the immune response. They capture and process antigens, present them on their cell surface in the context of major histocompatibility complex (MHC) molecules, and interact with T cells to activate them.
2. Cytokine production: Dendritic cells secrete various cytokines, such as interleukin-12 (IL-12), tumor necrosis factor alpha (TNF-α), and interferons, which help orchestrate the inflammatory response by recruiting and activating other immune cells, promoting tissue repair, and inducing antiviral or antibacterial responses.
3. Migration to lymph nodes: Following antigen uptake and activation, dendritic cells migrate from the site of infection or inflammation to nearby lymph nodes, where they interact with T cells. This facilitates the adaptive immune response by promoting the differentiation of antigen-specific T cells into effector or memory cells.
4. Regulation of immune tolerance: In addition to activating immune responses, dendritic cells also play a role in maintaining immune tolerance. They can induce the differentiation of regulatory T cells (Tregs) that help prevent excessive immune responses and autoimmunity.
Overall, dendritic cells are key players in the inflammatory response by initiating and regulating immune responses, controlling the balance between tolerance and immunity, and coordinating the interactions between different immune cells.