Consider the following events:

1) The protein has sugar added to become a glycoprotein.

2) The protein is in the plasma membrane with the sugar modification facing outside the cell.

3) A membrane protein is synthesized in the rough endoplasmic reticulum.

4) The glycoprotein is present in the membrane of a vesicle.

5) The sugars on the glycoprotein are modified.

6) The unmodified protein is present in the membrane of a vesicle.

What is the correct order of the events?

attempt at a solution: 3, 6, 1, 4, 5, 2

Why does hyaluronidase enhance the diffusion of injected drugs?

3,6,1,4,5,2

Ah, the chronicles of protein adventures! Let's put these events in the correct order, shall we?

3) A membrane protein is synthesized in the rough endoplasmic reticulum. The protein starts its journey here, like a rookie ready to be transformed.

6) The unmodified protein is present in the membrane of a vesicle. The protein is like a traveler in a vesicle, waiting for its glorious destiny.

1) The protein has sugar added to become a glycoprotein. Ah, the sweet transformation! Just like when you add sugar to your morning coffee and it becomes a fancy latte.

4) The glycoprotein is present in the membrane of a vesicle. The vesicle now houses the glycoprotein, all dressed up in its sugary attire. It's like a party inside a vesicle!

5) The sugars on the glycoprotein are modified. It's makeover time for our glycoprotein! It's getting a new look, fresh from the fashion designers of the cell.

2) The protein is in the plasma membrane with the sugar modification facing outside the cell. Finally, our transformed protein takes its place in the plasma membrane, ready to show off its modified sugars to the world. It's like the red carpet of the cell!

So, the correct order of events is: 3, 6, 1, 4, 5, 2.

To determine the correct order of events, we can examine the processes involved in the synthesis and modification of the protein, as well as the location of the protein at each stage.

Let's go through each event and analyze their order:

1) The protein has sugar added to become a glycoprotein.
This event involves the addition of sugar to the protein, which converts it into a glycoprotein. This typically occurs in the endoplasmic reticulum (ER) or Golgi apparatus. However, without any context about the location or timing, we cannot determine if this event occurs before or after the synthesis of the membrane protein. So, we'll keep it as a variable.

2) The protein is in the plasma membrane with the sugar modification facing outside the cell.
This event describes the positioning of the protein in the plasma membrane with the sugar modification facing the extracellular space. Since the protein must first be synthesized and modified before it can be incorporated into the plasma membrane, this event is expected to occur after events involving synthesis and modification of the protein.

3) A membrane protein is synthesized in the rough endoplasmic reticulum.
This event involves the synthesis of a membrane protein in the rough endoplasmic reticulum (ER). The protein is initially synthesized as a polypeptide chain and will undergo further processing to become a functional membrane protein. This event occurs before any modification is made to the protein.

4) The glycoprotein is present in the membrane of a vesicle.
This event suggests the presence of the glycoprotein in a vesicle's membrane. Considering the previous events, the unmodified protein is initially present in the membrane of a vesicle. Later, the protein undergoes modification to become a glycoprotein. Therefore, this event should occur after the unmodified protein is present in the vesicle's membrane (event 6) and before the sugars on the glycoprotein are modified (event 5).

5) The sugars on the glycoprotein are modified.
This event involves the modification of the sugars on the glycoprotein. Based on the previous events, this step is expected to occur after the protein has been modified into a glycoprotein (event 1), but before it is incorporated into the plasma membrane (event 2).

6) The unmodified protein is present in the membrane of a vesicle.
This event refers to the presence of the unmodified protein in the membrane of a vesicle. Since this event precedes the modification of the protein into a glycoprotein (event 1), it is reasonable to assume that this step occurs before the protein undergoes any sugar modification.

Considering the analysis above, we can arrange the events in the correct order: 3, 6, 1, 4, 5, 2

Therefore, the correct order of the events is:
3) A membrane protein is synthesized in the rough endoplasmic reticulum.
6) The unmodified protein is present in the membrane of a vesicle.
1) The protein has sugar added to become a glycoprotein.
4) The glycoprotein is present in the membrane of a vesicle.
5) The sugars on the glycoprotein are modified.
2) The protein is in the plasma membrane with the sugar modification facing outside the cell.