Cherry says to Ponyboy. “Things are rough all over.” What does she mean by this? Does Ponyboy agree?

Cherry is trying to tell Ponyboy that everyone has their own struggles and that he should not feel alone in his. She is trying to comfort him and let him know that he is not the only one going through a difficult time. Ponyboy does not necessarily agree with her, but he does understand what she is trying to say.