A physician calls and says that all the blood glucose results for his patients- from whom blood is drawn in his office and then sent to the laboratory – show low blood sugar/glucose. The physician states that there must be a problem with the laboratory instrument. What would you investigate to resolve the problem?

Measure insulin and glucagon levels in the blood. If blood glucose levels are too low, insulin levels will be too high and glucagon levels will be too low if nothing is wrong with the instrumentation used to measure glucose levels.

Just to add, I don't think anyone on this form know how specifically they measured blood glucose levels to know what's wrong with instrumentation.

Well, it sounds like this physician wants to get to the root of the "low blood sugar" mystery! Here are a few things I would investigate:

1. Sugar, sugar: Check if the blood samples are being stored properly. Perhaps the samples are being exposed to extreme temperatures, causing the blood glucose to break down and give false results. Nobody likes a hot mess!

2. Lab equipment: Take a closer look at the laboratory instrument. Make sure it's calibrated correctly and functioning properly. Maybe it's just having a sugar crash and needs a quick tune-up!

3. Human error: Investigate if any mistakes are being made during sample collection or handling. Perhaps the vampire nurses (I mean, phlebotomists) are accidentally adding preservatives or contaminating the samples with something funky.

4. Technical gremlins: Check the transport and storage conditions for the blood samples. Maybe they are being exposed to glitches in the matrix (or just rough handling) during transit, leading to wonky results.

So, with a bit of sleuthing, you'll hopefully crack this case of the mysteriously low blood sugar and save the day! Hopefully, you can put those patients' minds at ease and give them a sweet diagnosis.

To investigate the problem with the laboratory instrument causing consistently low blood glucose results, you should follow these steps:

1. Confirm the physician's claim: Request additional information from the physician to ensure that all blood glucose results from different patients consistently show low values. Verify if the issue is specific to the laboratory instrument or other factors could be contributing.

2. Check calibration and maintenance: Inspect the laboratory instrument to ensure it is properly calibrated and maintained. Improper calibration or insufficient maintenance can lead to inaccurate readings. Consult the instrument's user manual or contact the manufacturer for guidance on calibration and maintenance procedures.

3. Compare results with an alternate method: Perform blood glucose tests on the same patient samples using an alternative laboratory instrument or method. This can help establish if the issue lies with the specific instrument or if a systemic error is occurring.

4. Run quality control samples: Utilize quality control samples of known blood glucose concentrations during the testing process. These samples act as a benchmark to ensure the accuracy and reliability of the laboratory instrument. Check if the control samples provide expected results. If they don't, it suggests an issue with the instrument.

5. Conduct proficiency testing: Participate in proficiency testing programs offered by external organizations. These programs provide blind samples to assess the accuracy and precision of laboratory instruments. Comparing your instrument's results with these external assessments can help identify any discrepancies.

6. Analyze other factors: Investigate any potential sources of error outside of the laboratory instrument itself. Factors such as sample collection and handling, transportation, storage conditions, or even human error during the testing process can influence results. Ensure all relevant protocols are followed correctly.

7. Seek technical support: If the issue persists or remains unresolved, contact the laboratory instrument's manufacturer or technical support team. Explain the problem and provide all necessary details. They can provide further guidance, troubleshooting assistance, or advise on potential hardware or software issues.

By following these steps, you can systematically investigate the problem and identify the root cause of consistently low blood glucose results from the laboratory instrument.