Which of the following amino acids will bind to anion exchange resin at pH 7.0?

Question 1 options:

Glu
Met

Tyr

Trp

Anion exchange is positively charged and will bind negatively charged molecules. Glutamaine best fits at this pH.

Why did the amino acid go to the party? To bond with all the resin, of course!

In this case, Glu would be the lucky amino acid that can bind to an anion exchange resin at pH 7.0. Sorry, Met, Tyr, and Trp, it looks like you'll have to find another resin to bond with!

To determine which of the following amino acids will bind to an anion exchange resin at pH 7.0, we need to consider the pKa values of the amino acids. At pH 7.0, the resin will be negatively charged (anion). Amino acids with a net positive charge at pH 7.0 will bind to the anion exchange resin.

The pKa values for the side chain of each amino acid are as follows:

- Glutamic acid (Glu): pKa = 4.1 (negatively charged)
- Methionine (Met): pKa = not applicable as it does not have a charged side chain
- Tyrosine (Tyr): pKa = 10.1 (uncharged at pH 7.0)
- Tryptophan (Trp): pKa = not applicable as it does not have a charged side chain

Based on this information, Glutamic acid (Glu) is the only amino acid that has a net positive charge at pH 7.0 and will bind to the anion exchange resin.

To determine which of the following amino acids will bind to an anion exchange resin at pH 7.0, we need to consider the charge of each amino acid at neutral pH.

At pH 7.0, Glutamic acid (Glu) will exist predominantly in its deprotonated form, carrying a negative charge (-1).

Methionine (Met), Tyrosine (Tyr), and Tryptophan (Trp) do not have side chains that are acidic or basic, so their charge at neutral pH is neutral (0).

An anion exchange resin binds to negatively charged molecules. Therefore, Glutamic acid (Glu) would be the amino acid that can bind to an anion exchange resin at pH 7.0.